• Introducing NEW Cpf1 (a.k.a. Cas12a) Proteins1398/6/24

    Introducing NEW Cpf1 (a.k.a. Cas12a) Proteins
    In addition to our selection of Cas9 proteins for CRISPR experiments, abm now also offers Cpf1 (a.k.a. Cas12a) from the bacteria Francisella novicida for your genome editing experiments! Using Cpf1 in your CRISPR experiment offers several advantages over other CRISPR-associated nucleases:
    • Due to the T-rich PAM sequence (TTTN), Cpf1 enables editing in regions unable to be targeted by Cas9
    • Cpf1 can be used with a shorter guide RNA (called crRNA) than Cas9
    • Cpf1 creates a staggered cut in dsDNA instead of a blunt cut
    • Cpf1 cuts distal to the PAM sequence, which may allow for multiple rounds of cleavage

    Introducing NEW Cpf1 (a.k.a. Cas12a) Proteins